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Susan Anne Masino

Paul E. Raether Distinguished Professor of Applied Science, Trinity College
Chapter Member: Connecticut SSN
Areas of Expertise:

About Susan

Masino's research focuses on brain health and disease, natural processes and the ecological value of forests, and science-based, common-sense strategies for local and global wellbeing. Overarching themes in Masino's writings include adenosine, ketogenic diet, brain metabolism, and proforestation. Masino serves on the Simsbury Open Space Committee and is President of the Simsbury Grange, and the Hartford County Coordinator for the Old Growth Forest Network. She is on the boards of Aton Forest, the Pinchot Institute for Conservation, and Wellspring Common Stewards. Masino is currently a fellow with RESTORE: The North Woods.

Contributions

In the News

Opinion: "Connecticut’s Green Plan Must Preserve Our ‘Wildlands’," Susan Anne Masino, The Connecticut Mirror, December 19, 2023.

Publications

"Ketogenic Metabolic Therapy as a Treatment for Mental Health Disorders" (with Georgia Ede and Beth A. Zupec-Kania). Frontiers in Nutrition 12 (2025).

Explores the emerging field of metabolic psychiatry, which examines how metabolic dysfunction contributes to mental illness, and highlights the potential of ketogenic metabolic therapy as a new treatment for conditions like depression, anxiety, PTSD, and schizophrenia.

"Coordinating Old-Growth Conservation Across Scales of Space, Time, and Biodiversity: Lessons From the US Policy Debate" (with Carlos Carroll, Barry R. Noon, and Reed F. Noss). Frontiers in Forests and Global Change 8 (2025).

Examines the proposed 2024 National Old-Growth Amendment (NOGA) and its relevance to ongoing regional and national forest policies. Highlights the need for coordinated, long-term strategies to conserve old-growth forests in the U.S., focusing on biodiversity and climate benefits.

"Mechanisms of Ketogenic Diet Action" (with Robin S. B. Williams, Detlev Boison, and Jong M. Rho) in Jasper's Basic Mechanisms of the Epilepsies, edited by Jeffrey L. Noebels, Massimo Avoli, Michael A. Rogawski, Annamaria Vezzani, Antonio V. Delgado-Escueta, (Oxford University Press, 2024), 1635–1666.

Explores the various mechanisms through which the ketogenic diet (KD) helps treat medically resistant epilepsy. Highlights recent findings showing KD's broader effects, like anti-inflammatory, neuroprotective, and epigenetic benefits.

"The Importance of Natural Forest Stewardship in Adaptation Planning in the United States" (with Edward K. Faison and William R. Moomaw). Conservation Science and Practice 5, no. 6 (2023).

Argues that expensive forest management interventions are often unnecessary, have uncertain benefits, or are detrimental to many forest attributes such as resilience, carbon accumulation, structural complexity, and genetic and biological diversity. Advocates for natural forest stewardship as a cost-effective strategy for forest climate adaptation.

"Forest-Clearing to Create Early-Successional Habitats: Questionable Benefits, Significant Costs" (with Michael J. Kellett, Joan E. Maloo, Lee E. Frelich, Edward K. Faison, Sunshine L. Brosi, and David R. Foster). Frontiers in Forests and Global Change 5 (2023).

Provides a discussion of early-successional habitat programs and policies in terms of their origins, in the context of historical baselines, with respect to species’ ranges and abundance, and as they relate to carbon accumulation and ecosystem integrity. Calls for a reevaluation of forest and wildlife management policies to better balance efforts between creating early-successional habitats and ensuring long-term protection for mature and old-growth forests, along with more comprehensive monitoring and evaluation of these programs.

"Wildlands in New England: Past, Present, and Future" (with Foster, D.R., Johnson, E.E., Hall, B.R., Leibowitz, J., Thompson, E.H., Donahue, B., Faison, E.K., Sayen, J., Publicover, D. N., Sferra, N., Irland, L.C., Thompson, J.R., Perschel, R., Orwig, D.A., Keeton, W.S., Hunter Jr., M.C., Howell, and L), Harvard University, 2023.

Provides a critical baseline and a path forward for advancing policies and securing funding to accelerate Wildlands conservation in New England.

"A Companion to the Preclinical Common Data Elements for Proteomics, Lipidomics and Metabolomics Data in Rodent Epilepsy Models: A Report of the TASK3 Omics Working Group of the ILAE/AES Joint Translational Task Force" (with Bindila, L., Eid, T., Mills, J.D., Hildebrand, M.S., Brennan, G., Vicky Whittemore, V., Perucca, P., Reid, C.A., Patel, M., Wang, K.K., van Vliet, and V.A). Epilepsia Open (2018).

Focuses on proteomics, lipidomics, and metabolomics in epilepsy research. Outlines key parameters and case report forms (CRFs) for studies involving rodent models and humans with epilepsy, providing a rationale for the important elements to document in these methodologies to improve consistency and data quality.

"The Impact of Methodology on the Reproducibility and Rigor of Dna Methylation Data" (with Detlev Boison, Farah D. Lubin, Kai Guo, Theresa Lusardi, Richard Sanchez, David N. Ruskin, Joyce Ohm, Jonathan D. Geiger, and Junguk Hur ). Scientific Reports 12, no. 380 (2022).

Examines how minor experimental differences across laboratories can significantly affect epigenetic data, even under baseline conditions. Highlights the challenges of reproducibility in epigenomic research and stresses the need for strict protocol standardization to ensure reliable and interpretable results in neuroscience studies using animal models.

Ketogenic Diet and Metabolic Therapies: Expanded Roles in Health and Disease (Oxford University Press, 2022).

Provides a comprehensive overview of the ketogenic diet (KD) and its growing role in treating neurological and metabolic disorders. Explores the underlying mechanisms of the diet's effects, from ion channels to epigenetics, and examines how metabolism-based therapies can offer alternatives to pharmacological treatments, often with fewer side effects.